HPTA Upregulating Matrix – (SHBG Inhibition/ Cortisol Suppression)

(Lutenizing Hormone Elevation/ Free Testosterone Elicitation)

Tribulus Alatus (std. 70% ethanolic extract, aerial parts), a novel new relative of the tribulus family, has shown to yield significant increases in free serum testosterone levels when compared to controls in lab studies. Several alatus extracts were tested during this study and the ethanolic extract from aerial parts of the plant were shown to be the most efficacious. This is exactly the extract we use, exclusively, in Recycle™! (1)

Mucuna Pruriens (standardized for 20% L-Dopa) showed significant promise in regulating steroidgenesis by considerably increasing testosterone, Dopamine, Adrenaline, Noradrenaline and Growth Hormone amongst a field of 75 fertile and 75 infertile men. L-Dopa also contains natural secretagogues which aid in maintaining elevated endogenous Growth Hormone release by the pituitary gland. (2)

Basella Alba (10:1) has shown to have androgenic bioactive components increasing the testosterone production as well as increased testicular weight. (3)

Icariin (40% std. from Epimedium) is the most touted flavanoid found in horny goat weed. Lab studies have verified its  testosterone mimetic capabilities by improving circulating levels of testosterone and the condition of reproductive organs. This wonder ingredient has also been shown in vivo to be an estrogen receptor antagonist (blocking estrogen thus increasing testosterone), a vasodilator (allowing more nutrient carrying blood to the muscles), and an effective inhibitor of PDE-5. (4)

3, 4-Divanillyltetrahydrofuran (95% std. from Nettle Root), extracted at the highest purity from stinging nettle root, has shown in multiple studies to have the highest binding affinity for SHBG, which allows for more free-circulating testosterone. (5)

 

Aromatase Inhibition/ Estrogen Modulation/ DHT Block

Bladderwrack (Fucus Vesiculosis) has been shown to prevent the binding of estradiol and progesterone to their receptor sites, thus lowering endogenous levels of both, helping to maintain lower levels of body fat. (6)

White Button Mushroom Extract (Agaricus Bisporis) is loaded with aromatase inhibiting phytochemicals that are postulated to work through multiple inhibitory mechanisms, also aiding in the lowering of estrogen to help lower body fat. It has also been shown to inhibit the 5-alpha- reductase enzyme from binding to testosterone and converting it to DHT, the hormone responsible for male-pattern baldness. (7)

Trans-3,4’,5-trihydroxystilbene (Resveratrol), a polyphenolic compound structurally similar to estrogen, has received attention due to various potential health benefits. For our purposes, it is included for its proven testosterone boosting, anti-aromatization, and vasodilation properties. Resveratrol has been shown in lab studies to aid in increased blood testosterone levels and maintain healthy testicular sperm count. Countless other peer reviewed research studies support and substantiate this powerful ingredient’s positive effects. (8)

Indole-3-carbinol (40% std. for 3,3-Diindolylmethane) is a phytochemical found largely in cruciferous vegetables. One of its major metabolites is DIM (3,3-Diindolylmethane) which has been shown to steer estrogen metabolism in favor of "good" estrogen (2-hydroxyestrone/estradiol) and away from "bad" estrogen, such as 4-hydroxyestradiol. DIM represents a class of relatively non-toxic AhR-based anti-estrogens with SERM type qualities. A study done by University of California, Berkeley, showed through receptor binding assays that DIM is a strong competitive inhibitor of DHT binding to the androgen receptor. (9)

 

Absorption Amplification/ Glucoronidation Prevention/ CYP3A4 Inhibition

Quercetin & Piperine (Piper nigrum)
Supports increased bioavailability either by promoting rapid absorption from the gastrointestinal tract, by protecting the drug from being metabolized/oxidized in its first passage through the liver after being absorbed, or by a combination of these two mechanisms. All of which lead to increase the bioavailability of Resveratrol in vivo. (10)(11)

 

 

 

Resources:

  1. https://www.ncbi.nlm.nih.gov/pubmed/17767762/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816389/
  3. https://www.ncbi.nlm.nih.gov/pubmed/21339992
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551978/
  5. https://www.ncbi.nlm.nih.gov/pubmed/9434605
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514561/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201963/
  8. https://www.ncbi.nlm.nih.gov/pubmed/17872969
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847521/
  10. https://www.ncbi.nlm.nih.gov/pubmed/23625885
  11. https://pubchem.ncbi.nlm.nih.gov/compound/quercetin
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